Be Careful. Drug Interactions Can Be Fatal

Mixing OTC and prescription drugs can be dangerous. Tell your physician about every drug you are taking.Drug InteractionsOpioids can interact with a number of medications, including many over-the-counter drugs. One of the most dangerous interactions happens with allergy and cold medicines that cause drowsiness. When taken with opioids, this effect intensifies. It can slow the heart and breathing, increasing the risk of death.

Drugs that may interact with opioids include:

Alcohol

Ambien (zolpidem) and other sleeping aids

Antidepressants

Antifungals

Antipsychotics including Abilify (aripiprazole) and Haldol (haloperidol)

Benzodiazepines including Valium (diazepam) and Klonopin (clonazepam)

Carbatrol (carbamazepine), Lamictal (lamotrigine), Topamax (topiramate) and other anti-seizure medications

Clarithromycin and some other antibiotics

Muscle relaxers

Other opioids

Ref: https://www.drugwatch.com/opioids/#drug-interactions